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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
USP14
All Species:
18.48
Human Site:
S222
Identified Species:
27.11
UniProt:
P54578
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54578
NP_001032411.1
494
56069
S222
L
E
A
I
E
D
D
S
V
K
E
T
D
S
S
Chimpanzee
Pan troglodytes
P60051
493
55922
S222
L
E
A
I
E
D
D
S
V
K
E
T
D
S
S
Rhesus Macaque
Macaca mulatta
XP_001090667
458
52239
S194
S
V
K
E
T
D
S
S
S
A
S
A
A
T
P
Dog
Lupus familis
XP_537306
545
61461
S273
L
E
A
I
E
D
D
S
V
K
E
T
D
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9JMA1
493
55983
S222
L
E
A
I
E
D
D
S
G
R
E
T
D
S
S
Rat
Rattus norvegicus
NP_001008302
493
55958
S222
L
E
A
I
E
D
D
S
A
R
E
T
E
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519267
431
48760
G167
S
D
M
E
T
D
S
G
S
T
A
A
A
P
P
Chicken
Gallus gallus
XP_419150
492
55612
G220
Q
K
L
E
G
I
E
G
D
T
V
M
E
T
D
Frog
Xenopus laevis
Q6GNI6
523
60030
L218
M
Q
S
P
N
S
C
L
V
C
E
M
S
T
L
Zebra Danio
Brachydanio rerio
A6H8I0
506
58102
L226
S
P
H
I
P
F
R
L
L
H
L
V
W
T
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609377
475
53689
Q209
E
I
L
K
M
L
Q
Q
K
L
R
P
K
N
Q
Honey Bee
Apis mellifera
XP_395043
497
56311
L217
I
R
M
L
Q
Q
K
L
P
A
K
E
N
L
A
Nematode Worm
Caenorhab. elegans
Q17361
489
55859
I199
A
N
E
C
L
V
S
I
M
S
N
V
T
R
I
Sea Urchin
Strong. purpuratus
XP_786966
516
58357
D223
L
P
A
V
K
P
S
D
S
I
P
A
V
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q949Y0
482
53677
W202
Q
Q
D
A
E
E
C
W
T
Q
L
L
Y
T
L
Baker's Yeast
Sacchar. cerevisiae
P43593
499
57092
Q208
Q
G
G
F
Y
K
Q
Q
D
A
E
E
L
F
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
92.5
89.9
N.A.
96.7
96.5
N.A.
80.3
90.4
21.4
20.1
N.A.
54.6
61.7
41.9
61
Protein Similarity:
100
99.8
92.7
90.2
N.A.
98.5
98.7
N.A.
83.8
94.9
39
38.7
N.A.
71.2
80.2
61.1
76.5
P-Site Identity:
100
100
13.3
100
N.A.
86.6
80
N.A.
6.6
0
13.3
6.6
N.A.
0
0
0
13.3
P-Site Similarity:
100
100
20
100
N.A.
93.3
93.3
N.A.
13.3
26.6
40
20
N.A.
6.6
40
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.5
26
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
62.9
46.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
38
7
0
0
0
0
7
19
7
19
13
0
7
% A
% Cys:
0
0
0
7
0
0
13
0
0
7
0
0
0
0
0
% C
% Asp:
0
7
7
0
0
44
32
7
13
0
0
0
25
0
7
% D
% Glu:
7
32
7
19
38
7
7
0
0
0
44
13
13
7
0
% E
% Phe:
0
0
0
7
0
7
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
7
7
0
7
0
0
13
7
0
0
0
0
0
7
% G
% His:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
7
% H
% Ile:
7
7
0
38
0
7
0
7
0
7
0
0
0
0
7
% I
% Lys:
0
7
7
7
7
7
7
0
7
19
7
0
7
0
0
% K
% Leu:
38
0
13
7
7
7
0
19
7
7
13
7
7
7
13
% L
% Met:
7
0
13
0
7
0
0
0
7
0
0
13
0
0
0
% M
% Asn:
0
7
0
0
7
0
0
0
0
0
7
0
7
7
0
% N
% Pro:
0
13
0
7
7
7
0
0
7
0
7
7
0
7
13
% P
% Gln:
19
13
0
0
7
7
13
13
0
7
0
0
0
0
7
% Q
% Arg:
0
7
0
0
0
0
7
0
0
13
7
0
0
7
0
% R
% Ser:
19
0
7
0
0
7
25
38
19
7
7
0
7
32
32
% S
% Thr:
0
0
0
0
13
0
0
0
7
13
0
32
7
32
7
% T
% Val:
0
7
0
7
0
7
0
0
25
0
7
13
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _